Tumor delivery of chemotherapy combined with inhibitors of angiogenesis and vascular targeting agents
These changes, that led Jain and coworkers to formulate the hypothesis of " vascular normalization," should lead to a transient increase in vascular patency, a drop in IFP and alleviation of hypoxia, providing a " window of opportunity" for the delivery of drugs, with better therapeutic outcome. According to the hypothesis of vessel " normalization," →