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Age-related macular degeneration revisited: from pathology and cellular stress to potential therapies

The lack of treatments is in part due to the complexity of the disease, as not only multiple genetic and environmental risk factors but also different cell types within the inner and outer retina, have been shown to be involved in the pathophysiology of AMD. Herein, we will review the pathology and visual deficits associated →

Genetic ablation of g protein-gated inwardly rectifying k channels prevents training-induced sinus bradycardia

SAN pacemaking is generated by diastolic depolarization, a slow depolarizing phase of the action potential driving the membrane voltage from the end of the repolarization phase of the preceding action potential to the threshold of the following action potential. This delay was considered as a good compromise between the absence of the artifact due to →

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Supporting transgender inclusion and gender diversity in schools: a critical policy analysis

It is the policy frames informing the production of these texts, which rely on a fundamental logics of accommodation as a basis for addressing the problem of the need for trans inclusion, that is a critical focus in our analysis of these texts. It was the first school board in the country to develop a →

Flexible resource allocation during plant defense responses

Darwin cited the " law of compensation or balancement of growth" of Saint-Hilaire and Goethe from the early nineteenth century, quoting Goethe:" The budget of nature is fixed; but she is free to dispose of particular sums by an appropriation that may please her. For example, the roots and stems of many tree species alternate →

Non-additive effects in genomic selection

Shortly after the rediscovery of Mendel's rules, it was observed that, in some cases, the addition of the individual action of genes could not explain the mode of inheritance, and Bateson coined the term " epistasis" to describe the cases in which the actions of two or more genes interact. In the first, the dependence →

Reduce employee turnover in hospitality industry in pakistan business essay

In 1947, after the independence of Pakistan, after the independence of Pakistan the Nedous hotel was no longer existed because the nedous was not able to control the management of this hotel and ultimately Nedoud had to sake this hotel to the Avari group. It is made for those customers who first give a phone →

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The natural language processing tools english language essay

Both MUC, whichwas tagged with coreferring entities identified by noun phrases in the text and which represents small training and test sets, and ACE, which has much more annotation, but is restricted to a limited subset of entities, are less consistent, in terms of inter-annotator agreement, and thus diminish the reliability of the predictive models →

the merchant of venice in auschwitz: taking apart shylock using the scm and bias map

A tendency to see Shylock as the centre of the play, as opposed to Antonio, the Venetian merchant, appears in the historical record as early as 1598 when the play was listed in the Stationer's Register as " the Jew of Venice". He eventually saw Jean Gascon's production of The Merchant in 1970, at the →

Performance of recent ipos against credit ratings finance essay

I, Bhavarth Sheth student of Masters of Business Administration from Amity Business School, Amity University Uttar Pradesh hereby declare that I have completed Dissertation on " MANDATORY IPO GRADING: REFLECTIONS FROM THE INDIAN CAPITAL MARKET" as part of the course requirement. I would like to thank her for her continuous support, mellow criticism and able →

Advances in the prevention of infection-related preterm birth

The main cohort studies from Europe, North America, and Indonesia and three case control studies from the USA, Sweden, and Australia have used different methodologies to examine the association between abnormal genital tract microflora either in the form of bacterial vaginosis or the presence of BV-associated organisms and adverse outcomes of pregnancy. If BV is →

Toward psychiatry as a ‘human’ science of mind. the case of depressive disorders in dsm-5

As is well known in the philosophy of science, the term reductionism may have different meanings according to what exactly is held to be reduced: we may be reductionist in trying to reduce either the language of a theory T to the language of a reducing theory T , or the laws of T to →

Neuroscience of childhood poverty: evidence of impacts and mechanisms as vehicles of dialog with ethics

In addition, the evidence suggests that the influences of poverty on cognitive development are a function of the accumulation of risk factors, the co-occurrence of adversities, the individual's susceptibility to family and social environments, and the duration of the exposure to deprivations. In this context, the aim of this paper is to give to an →

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Minds, brains, and capacities: situated cognition and neo-aristotelianism

We must distinguish the claim that the brain and its parts are subjects of cognition the things which possess cognitive properties, are in cognitive states or undergo cognitive processes from the claim that they are the location of cognition. Since the subject of such neurophysiological processes and states is the brain or one of its →

What is youth political participation? literature review on youth political participation and political attitudes

The fourth section focuses on the political attitudes of young adults after reviewing political socialization research, for political socialization plays an important role in the formation of the political attitudes of young adults. In the fourth form, the political nature of the activities is based on contextual evidence, and only at the very last stage →

The involvement of noradrenaline in rapid eye movement sleep mentation

Dreaming and the brain: towards a cognitive neuroscience of conscious states. Pubmed Abstract Pubmed Full Text CrossRef Full Text Revonsuo, A." The reinterpretation of dreams: an evolutionary hypothesis of the function of dreaming," in Sleep and Dreaming.

Active intuition: the patterned spontaneity of decision-making

On the one hand, the patterns inherent in the ways in which individuals respond to situations, form lines of action, and conceive of themselves leads to the idea that individuals' most intimate drives and motivations may actually be deeply shaped by tacit, unconscious, deeply internalized cultural residua. I propose that keeping both mind and environment →

The iconographic brain. a critical philosophical inquiry into (the resistance of) the image

The eagerness of the press in this visual-centric time and age, where the image is a privileged commodity, is one thing, but the other more pertinent question is, what is the status of the image within wider culture, and more specifically, within scientific culture and science itself? In the fifth and final section, an engagement →

Using a transdisciplinary interpretive lens to broaden reflections on alleviating poverty and promoting decent work

According to the United Nations [UN], " The Decent Work Agenda promotes access for all to freely chosen employment, the recognition of fundamental rights at work, an income to enable people to meet their basic economic, social and family needs and responsibilities and an adequate level of social protection for workers and their family members". →

When the part mirrors the whole: interactions beyond “simple location”

The quest of the physicist and the philosopher is then to find out about those tiny building blocks, inquiring about the smallest of objects, in order to identify and characterize the constituents of reality. Or, quoting physicist and philosopher Ernst Mach's criticism of Newton: in the principle of inertia there is " an abbreviated reference →

Morphological processing as we know it: an analytical review of morphological effects in visual word identification

The aim of this paper is therefore to compile a list of reliable morphological effects in visual word identification that every model should be able to explain, in the hope that this will allow an easier adjudication process between existing theories and, if necessary, the development of new theories in a cumulative, nested fashion. These →

The brain’s best friend: microglial neurotoxicity revisited

However, microglia still rank among the most mysterious cells of the brain and only recent results have begun to provide answers to the most basic questions in microglial biology, for example the origin of these cells, or the fact that microglia are not replaced by peripheral monocytes/macrophages in the healthy situation. Indeed, the genetic removal →