Editorial: epigenetic regulation of stem cell plasticity in tissue regeneration and disease
A milestone of the last 20 years of scientific accomplishments is the possibility to modulate cell fate by reprogramming the transcriptional and epigenetic landscape of adult stem and differentiated cells. The reprogramming process per se and the remarkable transcriptional and epigenetic changes that are induced, exposes cells to mutational events and accumulation of epigenetic abnormalities.