Nmda receptor pathways as drug targets in cns therapeutics
Introduction: Glutamate is the king of excitatory neurotransmission in the central nervous system and acts on receptors located at the presynaptic terminal and in the postsynaptic membrane at synapses in the brain and spinal cord. The main agonists are glutamate and NMDA, with their binding site on NR2 subunits, while the binding site for the →