The Natural Sciences and Engineering Research Council of Canada was incorrectly identified as the National Science and Engineering Research Council of Canada. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Direct binding of TFEB to a 10-base site found in promoters of several lysosomal genes is required for the expression of CLEAR genes. 2009 PubMed Abstract CrossRef Full Text Google Scholar 10.
The study of drug target interactions is crucial for the discovery and development of new therapeutic molecules as the binding affinity of a ligand may provide important information about in vivo efficacy of the compound. For the characterization of a binding event and for the affinity screening of libraries of compounds as potential drug candidates, →
It is over-expressed in several different cancers, and is linked to tumor progression in ovarian cancer, poor prognosis in colorectal cancer, and cell migration, stemness, and cancer risk in breast cancer. They describe the expression of these ligands and receptors in breast cancer and propose further examination of APRIL and its receptors in breast cancer →
Using a comprehensive analysis of the publicly available data, a set of classification models was developed for predicting the inhibition of the transport for a set of liver transporters deemed relevant by different regulatory agencies. Accordingly, Velazquez-Libera et al.described a combined structure- and ligand-based approach for investigating the structural requirements governing the affinity of a →
In this paper, I explain the reasons for my low GMAT score, particularly in the verbal part. In conclusion, I hope I have explained the reasons for my GMAT score being low clearly and lucidly.
We should try and eat three servings of this group a day. It is important to eat a wide variety of fruit and vegetables.
In this context, it is required the transparency of methods section, which will benefit the evaluation of the Reviewers and the reproduction of the study as well. In view of these facts, it is hard for the pharmaceutical industry to apply the knowledge emerging from the majority of academic studies.
The roles of oxytocin and CD38 in social or parental behaviors. A role for autonomic cardiac control in the effects of oxytocin on social behavior and psychiatric illness.
We attempt to argue that the asymmetry in the self other distance ratings bias can be due to the self being a cognitive prototype in social perception or to the cognitive stereotypes of the other. The authors suggested that the more elaborate was the stereotype of the target compared to the self, the weaker was →
We present here a brief summary of the deterioration of the sensory and cognitive systems that occurs in older adults and we will present evidence that suggests that enriching the environment of the aging brain by reversing the decline in sensory systems may aid cognitive functioning. In noisy environments, older adults with hearing loss also →
The evidence from the available sources negates the claims of weight management programs expected success and the complexities and controversies in the supporting evidence are discussed insufficiently in the agenda of this current research. The findings of the research from the review of diabetic articles focused on weight loss are that, a.
Second, cost-sharing has the potential to improve efficiency in publicly financed health care, as it is expected that patients, when faced with the price of health care services, reduce the utilization of unnecessary and low-value health care. The ability of cost-sharing to generate revenues for the health sector is of particular interest to policy makers →
Lack of insulin leads to the high sugar levels in the kidney and therefore, the body tries to balance such high levels of sugar by retaining large amounts of water in the body, hence the low output of urine. Hodges kidney is affecting the rest of his body because it is associated with heart failure.
00070 Reason for Corrigendum: The authors, Jeanne A. The authors apologize for this oversight.
The Editorial on the Research Topic Fifty Shades of Grey: Exploring the Dark Sides of Leadership and Followership " I could stand in the middle of Fifth Avenue and shoot somebody and I would not lose any voters.Okay. The second theme accounts for the interaction between leaders' and followers' characteristics, and zooms in on the →
In conjunction with progress in theories of the pathophysiology of primary headaches, the understanding of the mechanisms of action of acute and preventive treatments for migraine and cluster headache has evolved. In the future, the study of patients with different types of headache and patients with other chronic pain disorders using machine learning techniques might →
Heath policy advocates should adapt cost-oriented measures that will work over a long time and should be guided by the following goals; encouraging more international competition to reduce treatment prices, reducing cost of malpractice coverage and the need for defensive medicine, ensuring treatment choices that are most effective and efficient, restoring more volunteerism to the →
Editorial on the Research Topic Extra-Corporeal Membrane Oxygenation in Pediatric Cardiac Patients Bartlett pioneered the use of Extra-Corporeal Membrane Oxygenation for prolonged cardio-respiratory support in critical patients in the 1970's, reporting on the first pediatric patient to survive: a young child with myocardial dysfunction after surgery for transposition of the great arteries. The advantages of →
Editorial on the Research Topic Molecular and Cellular Mechanisms in Reproduction and Early Development The growth and division of gamete cells are prerequisites for successful fertility and have received increasing attention in research communities. In this issue of Frontiers, a comprehensive review addresses the importance of this in the male gamete and the changes that →
The Editorial on the Research Topic Emotional Intelligence and Cognitive Abilities A quarter-century after Peter Salovey and John Mayer introduced the concept of emotional intelligence, it remains an important and growing research area. The link between cognitive ability and general intelligence is well-established, and evidence also suggests a link between cognitive ability and EI.
Need assessment are often conducted by organizations such as schools, social service agencies, business and government offices with the aim of helping determine the challenges and problems affecting them and thereby ways to mitigate. What services are likely to be suggested by a needs assessment?
A corrigendum on Comparative Genomics of the Zoonotic Pathogen Ehrlichia chaffeensis Reveals Candidate Type IV Effectors and Putative Host Cell Targets by Noroy, C, and Meyer, D.F. TABLE 1 Main biological and genetic characteristics of the eight Ehrlichia chaffeensis strains analyzed.
Jacomin et al.comprehensively describe the omics studies undertaken in the field of autophagy, and the integration of these omics datasets for better understanding of autophagy regulation and the involvement of autophagy in other biological processes. The authors also outlined the web-based resources for studying autophagy, such as for the prediction of Atg8-family interacting proteins, and →
We turned to Frontiers in an effort to help all interested in establishing a biobank to share some of their challenges, possible goals and standards for unification that might be taken into consideration globally if we are to develop systems that are truly comparable, translatable, actionable, and most importantly, take into account the ethics, safety, →
Despite significant advances in durable and non-durable ventricular assist devices for adult patients, ECLS remains the most commonly used form of mechanical cardiac and cardiopulmonary support in infants and young children. Since that time, a number of advances in ECLS equipment, refinements in surgical techniques, and growing recognition of an apparent survival benefit have led →
As of 30th January 2020, the outbreak of the novel coronavirus disease, later called COVID-19, was declared a Public Health Emergency and on the 11th of March 2020, COVID-19 was characterized as a pandemic. 1007/s40279-019-01183-w PubMed Abstract CrossRef Full Text Google Scholar Malm, C, Jakobsson, J, and Isaksson, A.
Shakespeare was born and lived through the medical renaissance, which was the point between 1400 and 1700 A.D.that innovated the medicines used in Europe. Each of these humors also relates to a substance from the body and a corresponding element, blood and air, yellow bile and fire, phlegm and water, black bile and earth respectively; →
Paul Fire and Marine Insurance Company v. Reference: Pennsylvania Insurance Company v.
We would like to point out that the genetic link between TBK1 and neurodegeneration is largely based on Mendelian dominantly inherited deleterious loss-of-function mutations, which are enriched in ALS/FTD patients and result in a loss of expression of one TBK1 allele. Association of mutations in TBK1 with sporadic and familial amyotrophic lateral sclerosis and frontotemporal →
Researchers have documented a positive association between social support and physical health and social support has been implicated in the etiology of disease and the success of treatment following illness. Social support and physical health: The importance of belonging.
One of the reasons why his work was never really that well established and well known was that at the time that he published his book on his findings, printing had only really just started to develop across the world, and this made a limited impact because of the fact that books at the time →
Thus, the classic adult dosing of 20 mg of hydrocortisone in the A.M.and 10 mg in the P. Hyperphagia in children with craniopharyngioma is associated with hyperleptinaemia and a failure in the downregulation of appetite.Eur.J.
Various situations in the preparation and use of veterinary pharmaceuticals based on cells are currently being observed: Autologous therapies by the veterinarian involving veterinary pharmaceuticals prepared by the veterinarian: the attending veterinarian extracts samples from the patient and processes this material in his medical office for the purpose of administering the resulting veterinary medicinal product →
Whereas, the default orientation allowed for the discovery of the ordinal position effect, the absence of left-to-right coding for serial order is not necessarily informative in itself: Does this mean there is no spatial coding overall, or is spatial coding oriented differently and/or with larger individual differences such that horizontally outlined response options cannot capture →
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In recent times, increasing cost of living has adversely impacted the public healthcare system in the United States. Thus, President Obama's healthcare reforms have been hailed as major initiatives which would address the problems of accessibility, cost paradigms and Medicare for the poor and needy.
From the engineer's point of view, all facets of touch can be enforced via tactile sensing to detect the act of being touched and tactile stimulation to elicit the feeling of being touched. To provide all required facets of touch, the HMI must mimic the human sense of touch and implement high sensitivity and distributed →
This rapid division results in large accumulation of the organism within the intestinal tract of the hosts beginning with the ileum and followed by infection of the duodenum and the large intestine. The time taken for the oocytes to be shed in the feces is about 4 days and they can be shed in the →
Designed experiments: MI, PC, MC, JR, and RC. PC and RC wrote the bulk of the manuscript, with significant contributions by MI and JR.
The trouble with that is that modern health facilities are not always available and they do not have a way to get health care. Overall, there are many contributing factors that lend to the problems Native American have with obtaining health care.
Craig asserts the basic purpose of homeostasis is " energy-efficient maintenance of the integrity and health of the body in support of the well-being and advancement of the individual and species". Rather, the intent is to allow an inclusion of the physical body in clinical work, if only through verbal interaction and within the therapist's →
The e-book starts with a review paper written by Zacher and Schmitt, in which the authors review research on the role of age in the relationship between psychosocial job dimensions and occupational well-being. In the Lee et al.paper, the direct associations of negative and positive work-to-family spillover on emotional exhaustion and job satisfaction are analyzed →
His mother presented with symptoms of chills, cough, and shortness of breath, and his father presented with symptoms of fever and congestion, leading to the diagnosis of COVID-19 infection. To our knowledge, this was the first case report of new-onset nephrotic syndrome reported in a pediatric patient associated with COVID-19 infection at the time of →
In three patients who underwent renal transplantation, the use of the IL-1RA anakinra in combination with MMF/azathioprine, tacrolimus and prednisone was safe and well tolerated. Before and after transplantation the dose of anakinra should be adjusted to the renal function, as this influences clearance.
Bitocchi et al.reviewed the origin of Phaseolus genus, the geographical distribution of the wild species, the domestication process, and the wide spread out of the center of origin. In particular for P.vulgaris, this resulted from the breaking of the spatial isolation of the Mesoamerican and Andean gene pools, which allowed spontaneous hybridization, and increasing the →
However, in spite of the growing amount of data available on the SARS-CoV-2, a clear understanding of how SARS-CoV-2 affects children is still missing. Cai et al.described the SARS-CoV-2 infection in 10 children and confirmed a mild presentation and, importantly, documented prolonged virus shedding from both the respiratory tract and the feces during the convalescent →
00043 In the original article, we neglected to include the patient consent statement. The original article was updated.
Editorial on the Research Topic High Performance Cognition: Information-Processing in Complex Skills, Expert Performance, and Flow In this Research Topic, High Performance Cognition emerges as a generic term for the study of human performance and skill acquisition, from novices on an unfamiliar task to experts displaying superior levels of domain-specific skill. The papers received in →
NO cortical interneurons have been historically classified as type I and type II on the basis of the size of their soma and by the intensity of their nNOS staining. 2010 Pubmed Abstract Pubmed Full Text CrossRef Full Text Tricoire, L, and Vitalis, T.
The representation of morphologically complex words in the mental lexicon and their neurocognitive processing has been a vigorously investigated topic in psycholinguistics and the cognitive neuroscience of language. Two studies, focusing on the role of semantic transparency and regularity in derived and inflected words indicate decomposition in semantically and phonologically opaque and transparent words in →
The original article has been updated and the new Author Contributions statement is: " RS and MW taught the study context. This classroom is part of a larger early childhood development center that is facilitated and associated with a small, public university in the southeast of the United States.
The spinal cord is supplied by a vast system of blood vessels comprising mainly the anterior spinal artery, the bilateral sulcal branches, the bilateral posterior spinal arteries, the pial arterial plexus as well as the anterior/posterior spinal veins, the anterior/posterior sulcal veins, and the pial venous plexus. The remaining 10 20% descends ipsilaterally as part →
Editorial on the Research Topic Advances in Mechanisms of Renal Fibrosis Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease and is considered a common pathway leading to end-stage of renal failure. The articles in this eBook describe advances in our understanding in the mechanisms of renal fibrosis that operate →
The theme of " neuronal variability" is of great importance in the characterization of the " inter and intra-subject variability," a concept that is becoming crucial to understand neuronal adaptation and plasticity in aging, and many pathological conditions of the brain. Furthermore, the concurrent or separated trial-by-trial analysis of the ongoing-EEG, EPs, ERPs and →
Western or Western-style conservatoires and music departments in the UK, Europe, US and Australia are the beneficiaries of this movement, facilitated not only by a general impetus to gain degrees in the West, but by the relative popularity of Western classical music tuition in China. Allemann-Ghionda, C." From intercultural education to the inclusion of diversity: →
01021 In the original article, there were two mistakes in the legends for the Kaplan Meier curves and the nomogram as published. We compared the predictive power for the prognosis of patients with PB between the nomogram, scope of tumor extension, and year of diagnosis.
The findings regarding the healthcare situation in Massachusetts relates to the containment goals aimed at reducing the cost of healthcare and increasing the number of people covered by health insurance policies. Therefore, the survey's outcomes signify the status of health insurance in Massachusetts after the initiation of the 2012 healthcare Bill.
Chevigny et al.have further added to the existing knowledge about the spatio-temporal expression of these TFs in the SVZ and the RMS and discussed the significance of this dynamic expression in specifying dopaminergic cell population in the OB. The authors observed that although in the PVZ, the expression of Dlx2 is restricted within the lateral →
Regarding influenza vaccine, a direct relationship of a strict linkage between this vaccine and GBS development was first supposed in 1976 when the receipt of a swine influenza vaccine in the USA was associated with a significantly greater than expected incidence of GBS. However, in this case, most of the studies revealed a slight but →
The center for disease control and prevention is among the organizations that have launched operations to monitor the prevalence of ASD within the US public domain. First, the network intended to provide an accurate count of the number of children that suffered from ASD within the sample sites.
The modern healthcare system must focus more on the current issue mainly because of the fast-changing environment that has significantly impacted the efficient delivery of healthcare. Moreover, the increasing number of uninsured population has become a huge concern as the health of people reflects a healthy economy and development.
Anencephaly is the condition when a neonate is born without a large part of the brain and skull. It is a neural tube defect which affects the tissue that grows in the brain and the vertebra.
In terms of the transferability of the face aftereffects, Keefe et al.have shown that trustworthy aftereffects transfer across different face identities and to opposite gender faces. Adaptation to antifaces and the perception of correct famous identity in an average face.
Aesthetic emotions include musical emotions, emotions of cognitive dissonances, emotions related to improving knowledge, in particular improving knowledge near the " top" of the mental hierarchy experienced as emotions of the beautiful. The theory of drives and emotions suggests that emotions and related feelings correspond to satisfaction or dissatisfaction of drives and instincts.
The implantation of a PNS conduit into both the ventral for motor recovery and dorsal part of the spinal cord for sensory recovery was performed in clinical cases of brachial plexus avulsion injury. The dorsal root injury is considered as a type of spinal cord injury and as such the most common spinal cord injury.
In this brief commentary we would like to focus on a particular subgroup of patients, that we would like to define as " modified Cluster B": in this population the dilation of ascending aorta represents the indication for operation in presence of a normally functioning bicuspid aortic valve and not dilated root. We assessed that, →
Editorial on the Research Topic Immunobiotics Interactions of Beneficial Microbes with the Immune System The term " immunobiotic" has been proposed to define microbial strains that are able to beneficially regulate the immune system of the host. Over the past few years, we have witnessed the emergence of robust development in the application of immunobiotics →
Background to the Disorder Signs and Symptoms Recognizing the signs and symptoms of dysgraphia is the foundation for treating and ultimately curing a child's disability. The study was conducted to evaluate the presence of dysgraphia in patients with AD-HD and was a successful.
To Jaspers, the subject of psychopathology was broadly " the individual as a whole in his illness, as far as it is a mental and psychogenic illness" and " the soul of the individual," respectively [, p.845]. In 2010, the Task Force on Nosology and Psychopathology of the World Federation of Societies of Biological Psychiatry →
This is mostly, because of the lack of will from the government officials and the lack of resources in the country, to provide health benefits to such a large population. Unfortunately, improving the system is not in their hands and has to be dealt with by the authorities.
Should the medical use of marijuana be legal in the US The medical use of drugs as pain relievers goes back in history to the first tribes; marijuana used for medical purposes has been legalized in Germany, Netherlands, Luxemburg, New Zealand, and other countries of the world are currently debating the issue. Based on the →
Heart Diseases in the United s Incidence and the Different Types of Heart Diseases In developed countries heart disease is at present the main cause of death, accounting for nearly two-thirds of fatalities annually in the United States. Thesis Statement: The purpose of this paper is to investigate the prevention of common heart diseases in →
Outcome 1 To have a duty of care means providing care and support for individuals within the law and also within the policies, procedures and agreed ways of working of the Employer. In situations where there is a conflict of interest or a dilemma between an individual's rights and my duty of care, it is →
With each passing day, I believe I am getting closer to this goal and this personal statement depicts my determination, strong will, commitment, and passion to succeed and I hope that it will serve to show my strong desire of working as public health officer opening the way for access to study public health at →
It is my will to work as an orthopedic specialist in sports medicine since I want to merge my love and experience for sports and my interest in science. Football also instilled the joy of hard work in me and I will apply it in all ways I can to ensure that I give my →
The greatest challenge that confronts the medical fraternity in the present age is the unavailability of other options with regard to the treatment of Parkinson's disease. In conclusion, it must be realized that the concept of fetal tissue transplant is a very important realization in the medical fraternity.
As previously alluded to, the presence of GLUT1 receptors on BRAF and KRAS mutated cells promotes this prooxidant effect of vitamin C in cancer cells. In summary, promising outcomes of vitamin C described in the management of KRAS and BRAF mutated colorectal cancer cells opened a new insight into treating aDTC.
The value of such networks for PPR control and eradication, as well as collaboration between laboratories in general, encouraged two meetings of the Global PPR Research Alliance after which the FAO and the World Organization for Animal Health established a Global Research and Expertise Network as an integral part of the PPR-Global Eradication Programme. The →
Patient management protocols are used in ensuring individualized care plans for clinical care in order to ensure safety and quality of clinical care. The guidelines and regulations provided in the protocols ensure that the caregivers are consistent in the management of clinic patients, a clear sign of compliance with the protocols.
Because I had a busy schedule, for a couple of weeks I could not practice my meditation, and I immediately felt the repercussions: I was becoming again easily annoyed, tired and my sleep disorder relapsed. After practicing meditation for two months continuously, I gained a healthy sleep and treated my anxiety.
The natural history of antibiotic resistance genes can be revealed through the phylogenetic reconstruction and this kind of analysis suggests the long-term presence of genes conferring resistance to several classes of antibiotics in nature well before the antibiotic era. Therefore, with the decline of the discovery rate, the mainstream approach for the development of new →
In this Topic, Fintha et al.provided a timely survey on the " fibroblast conversion" hypothesis, where epithelial cell transdifferentiation plays a crucial role in the generation of myofibroblasts, the main cells implicated in organ fibrosis. Magistri et al.analyzed the effect of the inhibition of Smoothened, an intracellular mediator of SHH signaling, in the control of →
1038/srep31721 Analysis of the transcriptome revealed the expression of a complete set of enzymes specific for a C 4 photosynthetic pathway in the pericarp of the developing wheat seed. Evidence for C 4 photosynthesis in the pericarp of cereals has been controversial because of uncertainties due to the difficulty of demonstrating flux of carbon through →
Although TB can be cured by chemotherapy, but the emergence of drug resistant tuberculosis [such as multidrug-resistant tuberculosis, extensively drug-resistant tuberculosis and totally drug resistant tuberculosis ] has created a new challenge to combat the adverse situation of the disease. Gupta et al.also reported that efflux inhibition with verapamil tremendously decreases the MIC of bedaquiline →
Many of these studies share as aims the need to characterize the subjective experiences and responses to triggers in those with misophonia, the relationship between misophonia and other conditions, and whether misophonia should be considered unique and distinct from established psychiatric disorders. For example, it is important to gain a more precise understanding of the →
These goals were selected based upon the CHNA we conducted, which analyzed and presented to the community primary and secondary data about community needs and priorities in Manhattan Community District 3 and in Sunset Park, including data from the New York City Department of Health and Mental Hygiene's Community Health Survey and the New York →
In physiological terms, the process consists of activation of the hypothalamic pituitary gonadal axis, which leads to the production of sex steroids and mature gametes as well as the ability to reproduce. The model of molecular timing most recently elucidated is the intracellular circadian clock, consisting of transcriptional translational feedback loops within each cellular oscillator, →
Also, it can be inferred that meteoritic impact, cosmic and solar wind flux variability coupled with the interior changes of the Moon may have manifested in the form of tectonic activity on the moon. The study therefore focuses on the identification of features indicating the presence of faults/lineaments/ fractures on the lunar topography using mini-SAR →
In the white matter, the role of Wnt7a/7b is reminiscent of vascular endothelial growth factor as the classical HIF1 /HIF2 target that is involved in angiogenesis and tissue architecture in the gray matter. In the report that first used the term " periventricular leukomalacia", the authors concluded from the location of the lesions at arterial →
With a myriad of interactions possible among the thousands of microbial species present in soils and between those species and plant roots, the intrinsic complexity of the system is enormous, and risks are high that attempts to stimulate a given plant-soil feedback might result simultaneously in the proliferation of pathogens or in problematic shifts in →
With the exception of bioremediation and enhanced oil recovery, most of these applications are still in the research and development phase in laboratories. A major challenge that impedes the development of further biotechnological applications for the petroleum industry is the complex, heterogeneous, and hazardous nature of crude oil and various distillates, residues and wastes.
Transformations in how energy is governed and produced, including the neoliberalization of energy markets and the rise of more distributed forms of energy production and renewables, have multiplied the roles that publics can and do take up in relation to energy. There is a need to look across a broader range of modes of energy →
00009 In the original article, the baboon imagewas inserted without the attribution to the author, Dr. The attribution of the image has now been inserted inFigure 3andFigure 4, and reads: Baboon image created by Kenneth Chiou, in " Population genomics of a baboon hybrid zone in Zambia", http://kennychiou.com/dissertation/#species.
Risk factors and the evolution of psychosis in 22q11. 1017/s0033291718002696 PubMed Abstract CrossRef Full Text Google Scholar Kendler, K.S." A gene for..".: the nature of gene action in psychiatric disorders.Am.J.
In the periodic paralyzes carbonic anhydrase inhibitors have traditionally been used as the treatment of choice and a recent RCT confirmed the efficacy of dichlorphenamide in hypokalaemic PP. Maggi et al.reported clinical and molecular features of a large cohort of patients with SCN4A gene mutations, clinically ranging from PP to NDM and to neonatal disease, →