- Published: January 19, 2022
- Updated: January 19, 2022
- University / College: University of Iowa
- Language: English
- Downloads: 23
A Corrigendum on
The Role Played by Mitochondria in FcϵRI-Dependent Mast Cell Activation
By Chelombitko MA, Chernyak BV, Fedorov AV, Zinovkin RA, Razin E and Paruchuru LB (2020). Front. Immunol. 11: 584210. doi: 10. 3389/fimmu. 2020. 584210
In the original article, there was an error. The statement that mitochondrial ROS inhibit the activity of NEMO is wrong. Mitochondrial ROS are crucial for the activation of the IKK-NEMO complex.
A correction has been made to the sectionThe Role Played by Mitochondria in the FcϵRI-Dependent Mast Cell Activation, subsectionMitochondrial ROS, paragraph 6. The correct paragraph appears below.
Mitochondrial ROS can stimulate NF-κB signaling by activating the kinase (IKK) of the inhibitor of NF-κB (IκB), which promotes its proteasome degradation and induces nuclear translocation of NF-κB ( 81 , 84 ). Mitochondrial ROS-dependent activation of IKK can be mediated by several mechanisms, including the formation of intermolecular disulfide bonds in NF-κB essential modulator (NEMO), a component of the IKK complex ( 85 ).
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
References
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