1,459
6
Essay, 2 pages (300 words)

Coronary artery disease

Chronic Endothelial injury Hypothesis- Endothelium protection and its repair are performed by glycosaminoglycan or GAGs when GAGs become weak, atherosclerosis is instigated. The process is promoted due to exposure of endothelial cells and free-radical damage. As the damage of endothelial lining is initiated the site promotes the permeability of plasma constituents especially the lipoproteins. Thus oxidized LDLs are capable of damaging the endothelial lining of the cells which results in the formation of plaque (Stephen, 2011).
Other contributing factors are immunological, inflammation, virus-related, or exposure to some chemical or mechanical resources prevalent in the environment.
When the endothelial cells are injured, the macrophages present in the blood move around from the blood circulation. The inner side of the artery forms a layer called a layer of the intima. Consequently, smooth muscles join intima along with connective tissue as well as lipids present inside as well as outside the cells to generate a plaque. This brings about union as well as accumulation of platelets, as well as release various growth-regulating factors to amplify the procedure ensuing obstruction of the lumen of the artery, leading to thrombus establishment (Mottillo, 2010).
Jeopardy Factors encompass
Modifiable- Obesity, Hyperlipidemias, Smoking, Alcohol consumption, Diet, Sedentary lifestyle.
Non-modifiable- Age, for female 55 and above, for males between 40- 55 Genetic predisposition or family history, Hypertension, Diabetes etc (Mottillo, 2010).
Reference
Mottillo, S., Filion, K. B., Genest, J., Joseph, L., Pilote, L., Poirier, P., Rinfret, S., Schiffrin, E. L., Eisenberg, M. J. (2010). The Metabolic Syndrome and Cardiovascular Risk: A Systematic Review and Meta-Analysis. J. Am. Coll. Cardiol, 56(14), 1113- 1132.
Pollard, J. (2009). Cognitive Maps of Women with Coronary Heart Disease: Describing the Content. Publisher: VDM Verlag Dr. Muller.
Stephen D. Wiviott, Marcus D. Flather, Michelle L. ODonoghue, Shinya Goto, Desmond J. Fitzgerald, Fernando Cura, Philip Aylward, Victor Guetta, Dariusz Dudek, Charles F. Contant, Dominick J. Angiolillo, Deepak L. Bhatt. (2011). Randomized Trial of Atopaxar in the Treatment of Patients With Coronary Artery Disease: The Lessons From Antagonizing the Cellular Effect of Thrombin–Coronary Artery Disease Trial. Circulation, 123, 1854-1863.

Thank's for Your Vote!
Coronary artery disease. Page 1
Coronary artery disease. Page 2
Coronary artery disease. Page 3

This work, titled "Coronary artery disease" was written and willingly shared by a fellow student. This sample can be utilized as a research and reference resource to aid in the writing of your own work. Any use of the work that does not include an appropriate citation is banned.

If you are the owner of this work and don’t want it to be published on AssignBuster, request its removal.

Request Removal
Cite this Essay

References

AssignBuster. (2022) 'Coronary artery disease'. 1 January.

Reference

AssignBuster. (2022, January 1). Coronary artery disease. Retrieved from https://assignbuster.com/coronary-artery-disease/

References

AssignBuster. 2022. "Coronary artery disease." January 1, 2022. https://assignbuster.com/coronary-artery-disease/.

1. AssignBuster. "Coronary artery disease." January 1, 2022. https://assignbuster.com/coronary-artery-disease/.


Bibliography


AssignBuster. "Coronary artery disease." January 1, 2022. https://assignbuster.com/coronary-artery-disease/.

Work Cited

"Coronary artery disease." AssignBuster, 1 Jan. 2022, assignbuster.com/coronary-artery-disease/.

Get in Touch

Please, let us know if you have any ideas on improving Coronary artery disease, or our service. We will be happy to hear what you think: [email protected]