Cd8+ t-cell repertoire in human leukocyte antigen class i-mismatched alloreactive immune response
The T-cell repertoire is initially shaped in the thymus by positive and negative selection of maturing T cells on self-peptide-HLA complexes and then modulated overtime at the periphery by the cumulative history of foreign antigenic exposures. While the CDR1 and CDR2 loops of the TCR interact primarily with cognate HLA molecules, the most variable region β