In the current issue of Frontiers in Medicine Gastroenterology, Nagpal et al.paid close attention to the role of gut in health and disease. A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis.Gut.doi: 10.
Through all of the medical breakthroughs, however, a handful stand out as the most important medical breakthroughs of the 20th century. 3) The Human Genome Project The crusade to map all human genes began in 1990 and was completed in 2003.
SFMCs were cultured with M-CSF, RANKL, or IL-7 for 10 days by replacing the medium at 3-day intervals with fresh cytokines as described in Figure 1. Roughness parameter and the number of pits were analyzed as described in Figure 1.
The high vulnerability of doctors and the high risks of their work contribute to the fact that they themselves are not inclined to trust the system in which they work. In the case of trust, people invest in the strengthening of their relations; in the case of mistrust, in the weakening of these relations and →
This contradiction stems from the fact that the industry, on one hand, provides cures to life-threatening diseases and at the same time is incapable of providing that cure to everyone at affordable prices. The fact that these drug companies are allowed to profit on the sickness of someone is upsetting.
This does not support the argument that love is merely an addiction. On the other hand, any addiction is contrary to this intimacy involved in love.
Studies of the effects of lithium contributed immensely to the identification of many of the known actions of GSK3 and to revelations that inadequately inhibited GSK3 is linked to a number of diseases, which includes FXS, as is reviewed here. Direct evidence that GSK3 may be involved in the pathology of FXS and be a →
Indeed, in a recent review of human color processing, Shapley and Hawken highlight the lack of knowledge of the blue yellow color processing channel as a pressing issue in color vision research by listing as one of the open questions of the last quarter century of research, " How are blue yellow signals processed in →
They describe the increased risk of breast cancer in nulliparous nuns and discuss the current studies attempting to define the role of the mammary stem cells, ER+ cells, and growth factors in parity-induced protection. Atashgaran and colleagues study the influence of the reproductive cycle on immune cells within the breast and how this might relate →
I read a story in the newspaper a few months back that said that a woman died because she could not make it to the hospital. Although I have spent much of my time in the area of medical research it is the interaction with patients that continues to draw me to the medical profession.
B plasmid was distributed from the Gradinaru Laboratory at the California Institute of Technology. The authors thank Viviana Gradinaru for her help in providing the AAV-PHP.
I and most of my friends had retainers and braces to maintain the image of good health with a picture perfect smile. She told me that health maintenance is highly valued and the government provides a number of health care services to the public.
And that part, in and of itself, informs the blind man's understanding of the elephant as the thing in itself. An idea blueprinted by Vygotsky, Dewey, and Bruner, and now instantiated in this series of papers, tackles the issues of learning, transfer, and experience with multiple metrics across domain general and specific processes and accounts →
The 1930s saw a rising interest in the idea of the unity of science, which is perhaps nowhere more visible than in the activities of one of the fathers of logical empiricism, Otto Neurath. As Pombo et al.put it: Neurath's own encyclopedic conception of the unity of science is built on the notion of cooperative →
Editorial on the Research Topic The Role of Genetic and Lifestyle Factors in Metabolic Diseases The study of gene environment interactions in metabolic disease has become an active research area in the last few years. It is worth noting that in observational studies the precision through which lifestyle exposure and outcome are assessed is usually →
The commonality of weight stigma and discrimination experiences for people with overweight and obesity means that internalization of weight bias is likely, and, with the associated impacts on health and health behaviors, is an important consideration across society. In editing this Research Topic, we have sought to present emerging empirical and theoretical contributions that advance →
This paper highlights two promising fields of pediatric neuro-oncology: the potential role of immunity modulation for treatment and the opportunity offered by the development of biomarkers to assist in the treatment of patients. In their paper, Laneve et al.tried to explain the function of long non-coding RNAs in the medulloblastoma biology and development.
Editorial on the Research Topic Multimodal and Longitudinal Bioimaging Methods for Characterizing the Progressive Course of Dementia According to the World Health Organization, in 2015 dementia affected 47 million people worldwide, a figure that is predicted to increase to 75 million in 2030 and 132 million by 2050. The aim of the Research Topic " →
From this perspective, at the core of compassion is courage and wisdom, in terms of courageous willingness and emotional strength to turn toward, empathically engage with and tolerate distress; and dedication to learn and develop skills/skillful means to take wise action in alleviating and preventing/halting suffering. Traditional martial arts philosophy and systems are commensurate with →
Advances in regenerative dentistry research over recent years have seen whole tooth bioengineering and the use of dental stem cells in a wide array of promising therapies. This corroborates findings from a more recent multicenter study that aimed to evaluate the knowledge and clinical applications of regenerative dentistry in dentists, specialist pediatric dentists, and endodontists.
The diversification and innovative technologies used by BASF has enabled it to sustain a large market presence, particularly in the non-cyclical product areas such as vitamins, crop protection, petrochemicals and plastics and fibers. With growth and innovative technologies, BASF has been able to increase its market value for the vitamins and pharmaceuticals while decreasing the →
Due to the nature of daily activities in school and places of work, it is difficult to brush teeth after every meal. Brushing teeth has no negative effects to a person if it is done properly using a good tooth brush and tooth paste.
What is the history of the eradication of smallpox? The World Health Organization was encouraged by the success in advanced countries and attempted to replicate this success in the rest of the world.
Obesity coupled with his metabolic syndrome, is making it hard for his body cells to react to insulin, and since his body is not able to generate sufficient insulin to supersede the resistance, his blood sugar level will increase considerably. It is therefore important to encourage him that, even a modest level of weight-loss of →
The typically time-series regression is suitable for estimating the effects of heat stress exposure over the period of time from one day to several days by comparing daily counts of deaths as an outcome variable with the temperature on the same day or over the last few days. The dependent variable in GAM is the →
The aim of this research topic forum was to highlight the progress made in this field via review papers and original articles as well as to promote future research with the aim to further understand the consequences of inter-individual difference in phase II metabolism and regulation of sex steroids. In the mini review by McNamara →
The utility of the article as a historical summary of dissenting theories of AIDS was recognized by the reviewers and editors, who accepted the article for publication. The article-type was changed to " Opinion" to better reflect the subjectivity of the subject matter and to clarify to the scientific community and broader readership that the →
Articles focus on all three types of IFN giving an important overview of current concepts of IFN functionality and emphasize the significance of IFN in immunity and beyond. Murira and Lamarre summarize in a mini review the role of IFN-I in chronic infections and discuss the role of IFN-I in immunopathology in different virally induced →
00036 In the published article, there was an error in affiliation for Bhusan K. In the published article, there was an error in the Conflict of Interest Statement.
First and foremost there is need to understand the billing of health care services. Accessibility of health care records to a greater amount of staff, physicians and clinicians is vital to ensure the speed of delivery and determine the individual cost of services offered.
Engaging in almost any type of physical activity facilitates glucose uptake, improves insulin sensitivity, and aids in glucose homeostasis by enhancing resting insulin action and lowering blood glucose levels for 2 72 h after the last bout of activity, depending on the exercise duration, intensity, and subsequent food intake. In a recent meta-analysis, aerobic, resistance, →
Given the high inter-dependence among the constituent parts of a living system and the non-intuitiveness of non-linear biological responses, the living organism may be viewed as a structure sharing the fundamental characteristics of " system of systems": autonomy, synergism, connectivity, diversity and resilience. The importance of the homeostasis hypothesis was the realization that " the →
These needs begin with physiological, which includes the automatic drive to fulfill one's basic nourishment fromfood, water and air, as well as the choices in the selection of these needs. This is a need to satisfy one's greatest curiosities in the final stage of self-fulfillment.
Conversely, only the group that received structured training showed a significant increase in the size of the motor map of the affected hand and amplitude of the motor responses to TMS. 21382 PubMed Abstract CrossRef Full Text Google Scholar Charles, J, and Gordon, A.M.
The assignment of the sex of rearing for patients with precocious diagnosis of ovotesticular difference of sex development is a complex decision. The goal of DSD therapy is the welfare of patients inside their families and in the society.
Editorial on the Research Topic Dendritic Cell-Based Immunotherapy in Solid and Haematologic Tumors The safety and feasibility of dendritic cell -based immunotherapies in the treatment of solid and hematologic tumors are well-documented. In this issue, original research by Kodumudi et al.highlighted that the timing and the schedule of ICI treatment and DC-based vaccination are fundamental →
Harm reduction has dominated the field in the last 40 years, but it would seem overwhelmed by current data indicating an increment in the diffusion, marketing, and abuse of psychostimulants like cocaine and amphetamines, a sector plagued by a lack of specific therapeutic tools, appearance on the drug market of new psychoactive substances like phenethylamines, →
Its approval by the US Food and Drug Administration for the prevention of stroke in patients with non-valvular atrial fibrillation was also a major development. One major disadvantage of Pradaxa is that its blood-thinning effect cannot be reversed once administered unlike in Warfarin which is reversible.
Cirrhosis is caused by the formation of tissues in the liver as the liver strains in its activities. In the process, the liver gets injured and in its repairing mechanism, there is the formation of scar fibrous material.
I would like to define and give an example of each of the behavioral traps, before I discuss which I think is the easiest to fall for and the easiest to avoid. Those are the five behavioral traps, I studied and read because to a point they all are easy to fall into, but one →
Primary resistance of Helicobacter pylori to levofloxacin and moxifloxacine in Iran. Efficacy of genotypic resistance-guided sequential therapy in the third-line treatment of refractory Helicobacter pylori infection: a multicentre clinical trial.
The role of ITCs in plant defense against pests and pathogens has been thoroughly described and multiple roles and functions for GLSs and their derived products suggested. A knowledge of the GLSs, their tissue and cellular localization and metabolism under various environmental conditions is important in the assessment of potential physiological effects.
Editorial on the Research Topic Phytohormones and the Regulation of Stress Tolerance in Plants: Current Status and Future Directions Stresses, either abiotic or biotic, severely affect agricultural productivity and world agriculture is facing the challenge of increasing the productivity in order to pace up with the increasing food demand of the growing population. The role →
In this Frontiers Research Topic, we present a selection of reviews, opinion, and original research articles mainly focused on the diverse and key roles of actin and tubulin cytoskeleton in neuronal biology, from neuronal migration, and differentiation during development to axon diameter regulation or dendritic spine formation and plasticity. They focus on different molecular mechanisms →
The hydroxyl group on the cholesterol molecule interacts with the phosphate groups of the membrane phospholipids, while the carboxyl groups interact with the carboxyl groups of the phospholipids. One of the changes is the increase in the levels of total cholesterol in the blood.
In this commentary on " Motor skill depends on knowledge of facts" by Stanley and Krakauer we aim to sketch an apparent contradiction in S&K's argument on the dependence of skills on knowledge of facts. A Dynamic Systems Approach to The Development of Cognition and Action.Vol.10.
Of particular interest were papers on time perception in humans and animals with a focused interest on embodied time perception as well as papers discussing the key role of time on different aspects of robotic cognition and the neural underpinnings of timing related phenomena. Time, emotion and the embodiment of timing.
The purpose of this Research Topic was to gather the latest knowledge in the field of monitoring and promoting physical activity and physical fitness in children. A systematic review of the relationship of physical activity and health status in adolescents.
In this, the focus will be on the implications BBIs may have on the individual at the CBI side of the BBI, i.e, on the recipient. As there was a time delay in between the encoding phase of the task and the behavioral response in the recipient animal, the study shows the transfer of a →
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As the scientific integrity of the article cannot be guaranteed, and adhering to the recommendations of the Committee on Publication Ethics, the publisher therefore retracts the article. The retraction of the article was approved by the Chief Editor of Frontiers in Cellular and Infection Microbiology.
The aim of this article is to review the current state of antibiotic use in Syria and clarify the main reasons behind the widespread irrational use of antibiotics in order to suggest venues of interventions. In Syria, the main source of health financing comes from the government's budget presented by the Ministry of Health and →
The technical challenge lies in the validation of the technology for the robust detection of a broad range of virus/hosts combinations and in determining the comparability of different approaches for acceptance in routine screening. Assuming a perfect performance of the bioinformatic analysis, sensitivity is directly linked to the proportion of viral RNAs among the cellular →
The free movement of goods and services under the auspices of the World Trade Organization and its General Agreement on Trade in Services and to the use of regional and bilateral trade agreements made patients, health professionals, medical technology and knowledge have been shared throughout the globe in the modern times which leads to new →
After years of advancing research into the causes, symptoms, and treatment of the disease, the health system seems to have identified a potential solution to managing the fatal condition. Complications of Systemic Lupus Erythematosus Research has revealed that this autoimmune disease contributes to the development of certain serious complications for patients.
In their recent Perspective Article, Lisman and Spruston succinctly describe the crucial shortcomings of spike-timing-dependent plasticity to serve as a unifying principle of synaptic plasticity. Pubmed Abstract Pubmed Full Text CrossRef Full Text Lisman, J, and Spruston, N.
The correct version of both instances of "" should be "". Also, the correct version of "" should be "".
Editorial on the Research Topic Proteoglycans and Glycosaminoglycan Modification in Immune Regulation and Inflammation While many publications cover proteoglycan and glycosaminoglycan research each year, to date there is still limited knowledge about the specific roles of these macromolecules in the regulation of immune responses and homeostasis. Wight et al.provide a comprehensive review on the regulatory →
Ice cube trays are filled with 1 kg of water at 18 C and placed in the freezer. The initial temperature of water is 25 C and the ice is intially at -15 C.
I will do much of purposive interrogation in order to know the measures they have taken to take care of their health conditions. I will identify and comprehensively describe the programs in place that have managed to prevent these health challenges these people face.3.
Next to this, as testicular physiology is under the control of the endocrine functions mainly through the activity of androgen and estrogen receptors, it was deeply studied if polymorphisms of genes involved in hormonal metabolism could be associated with a higher risk of TCs. Regarding the estrogen receptors, it was demonstrated that polymorphisms in ER →
For example, in a task requiring participants to locate an object hidden in the corner of a room, children rely on the room's shape, while adults use one of the walls painted in a distinct color from the other walls to find the object. Toward a theory of language-augmented thought," in The Psychology of Learning →
A collaboration between clinicians, researchers, and educational experts based in HICs and LMIC, the network, funded in part by a UK grassroots charity of the same name, links over 110 state and private sector hospitals and has trained over 4, 500 nurses and doctors in acute and critical care skills. Mobile applications linked to the →
01481 In the original article, there was an error in the URL provided in Data Availability Statement. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.
A scorecard could be developed to give scores on the variance of the actual diet with the perfect diet. Every child lives in a different environment, so it is exposed to different diet and lifestyle.
Being aware of this enables me to question my assumptions, accept that I am prone to error, and retain a degree of flexibility to correct myself when the evidence points out that I may have culturally stereotyped a patient at any time. The lesson for me in this is that I should be paying more →
The authors present a comprehensive summary of factors that induce and inhibit plus-and minus-strand transcription of the provirus and propose that the binding of the cellular factor CTCF to the provirus produces abnormal chromatin loops, resulting in changes of cellular gene expression and possibly favoring the development of ATL. In an investigation of the influence →
0036556 PubMed Abstract CrossRef Full Text Google Scholar Allemand, M, and Mehl, M.R." Personality assessment in daily life: a roadmap for future personality development research," in Personality Development Across the Lifespan, ed.J. 1016/0304-395902994-6 PubMed Abstract CrossRef Full Text Google Scholar Ryder, J, Longstaff, B, Reddy, S, and Estrin, D." Ambulation: a tool for monitoring mobility →
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Gavriilaki et al.provide an overview of the clinical landscape and pathophysiological " conundrum" of complement-mediated TMAs and critically address the feasibility of complement inhibition in a spectrum of TMAs with a pathogenic involvement of complement. The role of complement in neurological and neuropsychiatric diseases.
The DEAL model for critical reflection consists of three steps with prompts: detailed Description of the service experiences; Examination of those experiences in light of specific educational objectives; and the Articulation of Learning to set goals for improved future action by reexamining the source and contexts of practice. The theoretical framework of this survey research →
Abekhoukh and Bardoni review the potential roles of CYFIP1/2 in intellectual disability and autism, and their relation to fragile X syndrome. 038 PubMed Abstract CrossRef Full Text Google Scholar Banerjee, S, Riordan, M, and Bhat, M.A.
Indeed, Ravaisson seems to have found in the study of habit a key point for the solution of some of the fundamental problems of philosophy such as the relationship between mind and body, nature and freedom, and nature and culture. In this article we will examine how the study of the nature of habit applies →
00102 In our article entitled, " Long-term survival in a child with severe encephalopathy, multiple respiratory chain deficiency and GFM1 mutations," published in Frontiers in Genetics on 23rd March 2015 we inadvertently omitted information that the attending paediatrician believes may be relevant to the case. Given the relatively short duration of treatment and the neuroradiological →
The papers in the " Hydrothermal Vent" research topic cover a range of microbiological research in deep and shallow hydrothermal environments, from high temperature " black smokers," to diffuse flow habitats and episodically discharging subsurface fluids, to the hydrothermal plumes. The review synthesizes recent advances in the microbial ecology, physiology, and genomics of the mostly →
Editorial on the Research Topic Discovery and Total Synthesis of Bio-functional Natural Products From Traditional Medicinal Plants The term " natural product" refers to any naturally occurring substance, but it generally refers to a secondary metabolite. The Molecular Aspect of Natural Secondary Metabolite Products in Health and Disease.
018 PubMed Abstract CrossRef Full Text Google Scholar Bruns, A, and Eckhorn, R. 137 PubMed Abstract CrossRef Full Text Google Scholar von Stein, A, and Sarnthein, J.
The purpose of this piece is to provide an overview of current situation of cervical cancer screening and treatment programs in Botswana, to describe successes and challenges of the cervical cancer programs and highlight partnerships that have been significant to development of cervical cancer screening and treatment programs in Botswana. The Government of Botswana has →
It also reduces the impact of chronic disease and illness, and enhances flexibility, mobility and balance in the aging group. In addition, it was found that physical exercise improves sleep, boosts self-confidence and mood, and ultimately good for the brain.
Strengths and weakness of the arguments: Euthanasia and/or assisted suicide is a criminal offence in almost all countries throughout the world, however recently various countries have started to open up to consider the other side of the argument, and taken steps to legalize the process. Euthanasia, assisted suicide, and the philosophical anthropology of Karol Wojtyla.
On one hand, clinical professionals and hospitals provide information and allow supervision, while at the same time receive feedback from the Joint Commission process in order to improve. About three years ago, the Joint Commission was chosen as an independent organization to determine how technology could lead to mistakes in the health process and how →
These three planes are the sagittal plane, the frontal plane and the transverse plane. Frontal plane movements include adduction and abduction of limbs in the plane.
In the case of snakebite and other envenomations, the antiserum is the only effective treatment. 457 PubMed Abstract CrossRef Full Text Google Scholar 10.
Atherosclerosis is still a great burden on human health and scientific achievements of the past 30 years have definitively proven the inflammatory causes of the disease highlighted by the results of the CANTOS trial. More studies focusing on the role of T lymphocytes and adaptive immunity in the natural history and pathogenesis of atherosclerosis are →
Based on the view that a destination image is dependent on context, the authors have discussed the impact of analyzing differences of " perceived destination image effects" on the satisfaction and intentions of potential visitors. More specifically, DMOs are non-profit entities that organize and provide tourism information for a given geographic area and coordinate the →
The serious failures and issues range from a lack of communication and reporting, to physical and mental abuse, and a lack of training and acceptance of responsibility in both cases. The report published on Winterbourne View showed that Castlebeck Care Ltd were not compliant with 10 of the essential standards which the law requires care →
From their writings, It could be noted that the views of the authors upon the relation of natural wealth with the wealth of human individuals which they primary have in themselves. This particular behavior relates the human creation towards the fact that they are able to make possible adjustments in their lifestyle depending on theenvironmentthat →
Rapidly evolving technologies in genomics and computational science are now opening up a new avenue for elucidating the real picture of diversity of the organism in nature and for studying the principles underlying the maintenance and change of structures, interactions, and functions of biomolecules. They describe recent advances in understanding of the biogenesis and functions →
A corrigendum on Generating functionals for computational intelligence: the Fisher information as an objective function for self-limiting Hebbian learning rules by Echeveste, R, and Gros, C. 00001 In formula of the Fisher information with respect to the synaptic flux was formulated formally as an integral over the postsynaptic activity y, without stating explicitly that the →
Hence, one of the most important challenges facing the development of sustainable solutions to current and future environmental problems is finding ways to bridge the gap between fundamental research and applied management, conservation and restoration of ecosystems. Over the past decades, the case has been amply made in the scientific literature for the usefulness of →
Upon arrest, he was completely unaware of the severity, of the social and moral disvalue and of the legal implication of his behavior. In particular, the cognitive profile of the defendant was worsened as reflected by the decline in daily living autonomy, which is an important aspect for the diagnosis and progression of dementia, and →
Editorial on the Research Topic Structural Valve Degeneration and Failure in Transcatheter and Surgical Bioprosthesis With the increasing prevalence of valvular heart disease worldwide, the need for heart valve replacements is expected to hit as well. The article by Sawaya et al.is a critical review of the standardized criteria to define SVD and valve failure →
Individual Differences Behaviour is the result of interaction between individual characteristics and the characteristics of the environment in which the behaviour occurs. Some of the other definitions are " Personality is a vehicle to integrate perception, learning, values and attitudes and thus to understand the total person." " Personality is an individual's total sense of →
1093/hmg/ddu377 PubMed Abstract CrossRef Full Text Google Scholar Mairet-Coello, G, Courchet, J, Pieraut, S, Courchet, V, Maximov, A, and Polleux, F. 0709336105 PubMed Abstract CrossRef Full Text Google Scholar Schrank, S, Barrington, N, and Stutzmann, G.E.
The line in the Abstract section: " The use of a breast pump was significantly associated with composition of HMM, lower microbial load, and higher abundance of cultivable staphylococci," was not correct. A correction has been made to the Abstract: " The use of a breast pump was significantly associated with composition of HMM, higher →
During the multiple-dose phase the incidence of treatment-emergent adverse events was 67% in the IV LEV group and 33% in the placebo group. After these tests were used to determine the baseline function, a 1, 000 mg dose of LEV was administered to measure the pharmacokinetics of LEV and UCB L057.